In 1993 he was convincing as a young John F. Kennedy in the 2-part TV mini-series JFK: Reckless Youth. In 2004, he co-starred in the highly acclaimed HBO production, Iron Jawed Angels, opposite Hilary Swank and Anjelica Huston. He also appeared as special guest star in The Practice for 3 episodes finale season (8x13-8x15), as a married man who murdered his lover.
Dempsey had a high-profile role as one of the suitors for Reese Witherspoon in Sweet Home Alabama. He also had a role as Detective Kincaid on Scream 3. He is expected to return in a possible Scream 4. Dempsey's most recent roles include the 2007 Disney film Enchanted, and the Paramount Pictures film Freedom Writers where he reunites with his Iron Jawed Angels co-star Hilary Swank. He also voiced the character Kenai in Brother Bear 2.
Most recently, Dempsey has starred in Made of Honor as Tom.
DreamWorks Animation announced Patrick Dempsey voiced the dinosaur knight called the Aurora Defender (similar to Magna Defender) in the live-action/animated movie version of Tom and Jerry.
Patrick Dempsey is scheduled to begin filming the upcoming movie "Blood, Sweat and Tears" in Chicago in September of 2009. Dempsey will play a powerful record company executive in this music-filled action-comedy produced by David Johnson.
Patrick Dempsey and Eric Dane are bound for the same big-screen project, joining the estimable ensemble for the romantic comedy Valentine's Day. The Garry Marshall-directed film follows five interconnecting stories about Los Angelinos anticipating (or in some cases dreading) the holiday of love.
Grey's Anatomy
Dempsey has received significant public attention for his role as Dr. Derek Shepherd in the drama Grey's Anatomy. Prior to landing the role of Derek Shepherd, Dempsey auditioned for the role of Dr. Robert Chase on another medical show, House. Initially a midseason replacement, the show was very well received and has become a highly rated program. Media attention has been focused on Dempsey's character Derek, often referred to as "McDreamy", for his sex appeal, and the character's romance with intern Meredith Grey (played by Ellen Pompeo).
Dempsey was nominated for Best Performance by an Actor in a Television Series – Drama at the 2007 Golden Globes for the role. In 2006 Dempsey signed a contract with ABC raising his salary to $225,000 per episode. His success on the show has led to him becoming a spokesman for Mazda and a model for Versace. He has also been the spokesman for several recent State Farm advertisements. He is currently working with Avon to launch a fragrance, due out in November 2008, which is called Unscripted.